Each question starts with what the filings show, then why it matters. None of these is a rating or a forecast.
How concentrated is revenue in incretins?
Mounjaro and Zepbound together accounted for 56% of 2025 revenue, with Mounjaro at $23.0 billion and Zepbound at $13.5 billion, and six products made up 82% of the $65.2 billion total. Item 1A flags this dependence on relatively few products and on three wholesalers; monitor U.S. realized prices, which fell even as volume surged.
What is happening to pricing and access?
The 10-K describes preliminary voluntary agreements with the U.S. government announced in November 2025 to lower Medicaid and certain other prices and to launch new medicines with more balanced pricing across developed nations, plus CVS Caremark's July 2025 removal of Zepbound as a preferred option. Model these against outside-U.S. revenue of $21.7 billion.
Can manufacturing keep up with demand?
Item 1 lists capacity investments at new sites in North Carolina, Wisconsin, Indiana, Virginia, Texas, Alabama, Pennsylvania, Ireland, Germany, and the Netherlands, and Item 1A notes that adding capacity takes years and regulatory approvals. Compare capital spending with the supply commentary and with R&D expense of $13.3 billion.
How durable is the profit margin?
Gross margin reached 83.0% of revenue in 2025 and audited net income was $20.6 billion, or $22.95 per diluted share. Item 1 gives Mounjaro/Zepbound compound patent protection to 2036 in the U.S. but data protection only to 2027, and notes continued mass-compounded incretins; weigh these against orforglipron's regulatory review.
Does LLY's reported profit turn into cash?
Operating cash flow was $16.8B, 0.81 times net income of $20.6B, for the fiscal year ended December 31, 2025.
Cash from operations trailed reported earnings. Working-capital build (receivables, inventory, prepayments) or non-cash gains are the usual reasons; check the cash-flow statement before relying on reported profit.
Form 10-K filed February 12, 2026
How much of LLY's revenue is left as profit?
Net income was 31.7% of revenue for the fiscal year ended December 31, 2025, based on revenue and net income reported for the same period.
Net margin reflects the business model as much as execution, so compare it with companies in the same SEC industry and read the income statement for one-time items before treating it as a run rate.
Form 10-K filed February 12, 2026